Red List
UPB
Upstream Bio, Inc.
Healthcare · Biotechnology · small-cap ($414M)
-73.9%
from rolling 252-day high of $33.68 set 2026-01-14 · 120d ago
Current
$8.79
Decline depth
-73.9%
Decline σ
6.7σ
TFC
4/5 bearish
Rolling 252-day high Up day Down day Last 90 trading days · data from Alpaca

Structural break signals

UPB qualifies for the Red List on decline depth.

Decline depth
-73.9%
From rolling 252-day high of $33.68, 120d ago. Past the 40% Red List threshold.
Time-frame continuity
4/5 bearish
Latest bar across daily/weekly/monthly/quarterly/yearly time frames. A bar counts as bearish when it's a 2-Down or a red 3. Past the 4/5 Amber threshold.
Decline sigma
6.7σ
Drop from local high over the last 20 bars, expressed in units of the stock's typical daily volatility (2.98% per day). Past the ≥6σ Amber threshold.

The structural read

What price action says about UPB.

UPB qualifies for the Red List on decline depth — down -73.9% from its rolling 252-day high. Past the 40% threshold, the deepest tier in the taxonomy. Depth plus recency: this is the pattern many investors call a falling knife.

Cross-confirmation: also showing 4/5 bearish time frames.

Cross-confirmation: decline sigma also reads 6.7σ over 20 bars.

Upstream TFC read: bearish alignment, current phase daily. Last bar types — daily 3 (red), weekly 3 (red), monthly 2D (red).

52-week range

52W low $5.14 12.8% of range 52W high $33.68

Sector context · Healthcare

182 other Healthcare tickers are on Broken Stocks.

92 Red List
43 Amber
47 Watch
-35.8% Median decline

Worst in sector: OPRX (-76.7%). Least-bad: ANIP (-20.0%). See all Healthcare listings →

Questions about UPB

What people ask.

Why is UPB on Broken Stocks?

UPB qualifies for the Red List on decline depth. It is down -73.9% from its rolling 252-day high of $33.68, set on 2026-01-14 — 120d ago.

Is UPB a falling knife?

By the most common technical definition — a steep, recent breakdown from a fresh high — yes. UPB is down -73.9% from its 52-week high of $33.68, set 120d ago. That combination of depth (past the 30% Amber threshold) and recency (high set inside the last 120 days) is the textbook falling-knife pattern. Whether to try to catch it is a separate question — historically most attempts to bottom-pick continue lower before reversing. Broken Stocks flags the pattern; it does not recommend buying or selling.

Is UPB a buy?

Broken Stocks does not issue buy or sell recommendations. The list is a rules-based technical warning system. It tracks structural decline depth and recency — not company quality, management, fundamentals, or news. Always do your own research and consult a licensed advisor.

Where is UPB trading inside its 52-week range?

At $8.79, UPB sits 12.8% of the way from its 52-week low ($5.14) to its 52-week high ($33.68). A reading below 25% indicates price is hugging the bottom of the range; above 75%, the top.

How fast has UPB been declining?

The current 73.9% decline accrued over 120d, which annualizes to roughly -224.8% per year. Annualized pace is a sanity check — a 30% decline in three months is a different signal than a 30% decline over two years.

How does UPB compare to its sector?

There are 182 other Healthcare tickers on Broken Stocks: 92 Red, 43 Amber, 47 Watch, with 55 showing recovering structural signals. Median sector decline is -35.8% — UPB's decline is deeper than the sector median.